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中国计量大学硕士生导师信息表

基本信息

姓名: 郭良宏 性别: 学位: 博士
职称: 研究员 一级学科: 安全科学与工程 二级学科: 安全科学与工程
二级学院: 生命科学学院 一级学科2: 生物学 二级学科2: 生物化学与分子生物学
研究方向: 环境污染与健康 环境污染物风险评估 化学品安全性评估 环境污染物的危害机制 办公地点: 方正楼314室
办公电话: 86876235 移动电话: Email: LHGuo@cjlu.edu.cn

在研课题

1.  英国皇家学会国际合作基金项目:“China-UK Research for Safeguarding Natural Water”(IC160121), 2017-2021,在研,Co-PI (with Prof. John Colbourne, University of Birmingham, UK).
2.  国家基金委重大研究计划重点项目:“基于颗粒物模型研究PM2.5氧化应激效应的分子机制”(91543203),290万,2016.01-2019.12,在研,负责。
3.  国家基金委重大科研仪器设备研制项目:“高通量多功能成组毒理学分析系统”(21527901),300万,2016.01-2020.12,在研,参与。
4.  中国科学院前沿科学重点研究项目:“多溴联苯醚生殖发育毒性的关键生物通路”(QYZDJ-SSW-DQC020),300万,2016.07-2020.06,在研,负责。
5.  国家基金委创新研究群体:“持久性有毒污染物的环境过程与毒理效应”(21621064),50万,2017.01-2019.12,在研,参与。
6.  中国科学院先导专项B项目课题:“典型内分泌干扰物与激素相关生物大分子相互作用研究”(XDB14040100),885万,2014.07-2019.06,在研,负责。

获奖情况

2010 中国科学院优秀研究生导师奖 
2013 中国科学院杰出科技成就奖 (主要完成人)
2013 国家百千万人才工程“有突出贡献中青年专家”
2015 中国分析测试协会科学技术奖二等奖(排名第二)
2015 国务院政府特殊津贴

近期发表的主要成果

(1) Hui Zhang, Weimin Wang, Huanxin Zhao, Lixia Zhao, Li-Yong Gan, Liang-Hong Guo*
“Facet-Dependent Interfacial Charge Transfer in Fe(III)-Grafted TiO2 Nanostructures Activated by Visible Light”
ACS Catalysis, 2018, 8, 9399?9407. 

(2)  Yan Xin, Bin Wan*, Yu Yang, Xue?Jing Cui, Yi?Chun Xie, Liang-Hong Guo*
“Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells”
Archives of Toxicology, 2018, 92, 3131-3147.

(3)  Yan Xin, Xiao-Min Ren, Ting Ruan, Chuan-Hai Li, Liang-Hong Guo*, Guibin Jiang
“Chlorinated Polyfluoroalkylether Sulfonates Exhibit Similar Binding Potency and Activity to Thyroid Hormone Transport Proteins and Nuclear Receptors as Perfluorooctane sulfonate”
Environ. Sci. Technol. 2018, 52, 52, 9412-9418.

(4)   Dabin Wang, Lixia Zhao*, Dan Wang, Li Yan, Chuanyong Jing, Hui Zhang, Liang-Hong Guo*, Ning Tang
“Direct evidence for surface long-lived superoxide radicals photo-generated in TiO2 and other metal oxide suspensions”
Phys. Chem. Chem. Phys., 2018, 20, 18978-18985.

(5)   Lin-Ying Cao, Xiao-Min Ren*, Yu Yang, Bin Wan, Liang-Hong Guo*, De Chen, Yong Fan
“Hydroxylated Polybrominated Diphenyl Ethers Exert Estrogenic Effects via
Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways”
Environmental Health Perspectives, 2018,126, doi: 10.1289/EHP2387.

(6)   G. Qin, J. Xia, Y. Zhang, L. Guo, R. Chen, N. Sang*
“Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice”
Particle and Fibre Toxicology, 2018, 15-27.

(7)   Yin-Feng Zhang, Xiao-Min Ren, Yuan-Yuan Li, Xiao-Fang Yao, Chuan-Hai Li, Zhan-Fen Qin*, Liang-Hong Guo
“Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo”
Environmental Pollution, 2018, 237, 1072-1079.

(8)  Chuan-Hai Li, Xiao-Min Ren,* Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo,* Guibin Jiang
“Chlorinated Polyfluorinated Ether Sulfonates Exhibit Higher Activity toward Peroxisome Proliferator-Activated Receptors Signaling Pathways than Perfluorooctanesulfonate”
Environ. Sci. Technol. 2018, 52, 3232?3239

(9)   Hai-Yan Ma, Lixia Zhao,* Da-Bin Wang, Hui Zhang, Liang-Hong Guo*
“Dynamic Tracking of Highly Toxic Intermediates in Photocatalytic Degradation of Pentachlorophenol by Continuous Flow Chemiluminescence”
Environ. Sci. Technol. 2018, 52, 2870?2877

(10)   Lin-Ying Cao, Xiao-Min Ren,* Chuan-Hai Li, Liang-Hong Guo*
“Organophosphate Esters Bind to and Inhibit Estrogen-Related Receptor γ in Cells”
Environ. Sci. Technol. Lett. 2018, 5, 68?73

(11)   Yuxin Gu, Yu Yang,* Bin Wana, Minjie Li, Liang-Hong Guo*
“Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells–A molecular mechanism of organophosphate flame retardants developmental neurotoxicity”
Biochem. Pharmacol., 2018, 152, 21–33

(12)   王丹,赵利霞*,张辉,郭良宏
“二氧化钛光催化产生超氧自由基的形态分布研究”
《分析化学》,  2017, 45, 1882-1887

(13)   Tianyi Dong, Yanping Peng, Ning Zhong, Fengyan Liu, Hanyu Zhang, Mengchen Xu, Rutao Liu, Mingyong Han, Xingsong Tian, Jihui Jia, Lap Kam Chang, Liang-Hong Guo,* Shili Liu*
“Per?uorodecanoic acid (PFDA) promotes gastric cell proliferation via sPLA2-IIA”
Oncotarget, 2017, 8, 50911-50920

(14)   Dan Wang, Lixia Zhao,* Haiyan Ma, Hui Zhang, Liang-Hong Guo*
“Quantitative Analysis of Reactive Oxygen Species Photogenerated on Metal Oxide Nanoparticles and Their Bacteria Toxicity: The Role of Superoxide Radicals”
Environ. Sci. Technol. 2017, 51, 10137?10145

(15)   Lin-Ying Cao, Xiao-Min Ren,* Chuan-Hai Li, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo*
“Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway”
Environ. Sci. Technol. 2017, 51, 11423?11430.

(16)   Rui Feng, Gang Liang, Liang-Hong Guo*, Yi-Ping Wu 
“A chemical toxicity sensor based on the electrochemiluminescence quantification of apurinic/apyrimidinic sites in double-stranded DNA monolayer”
Sensors and Actuators B, 2017, 248, 512–518.

(17)   Yu Yang*, Yuxin Gu, Bin Wan, Xiaomin Ren, Liang-Hong Guo*
“Label-free electrochemical biosensing of small-molecule inhibition on OGlcNAc glycosylation”
Biosensors and Bioelectronics, 2017, 95, 94–99.

(18)   Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*
“Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells”
Scientific Reports, 2017, 7, 1518 (DOI:10.1038/s41598-017-01746-9)

(19)   Yu Yang, Qi?Yan Lv, Liang?Hong Guo*, Bin Wan, Xiao?Min Ren, Ya?Li Shi, Ya?Qi Cai
“Identification of protein tyrosine phosphatase SHP?2 as a new target of perfluoroalkyl acids in HepG2 cells”
Arch. Toxicol., 2017, 91, 1697–1707.

(20)   Liang-Hong Guo
“Haze and Health”
National Science Review, 2016, 3, 412–413.

(21)   Cui, X.; Wan, B.*; Yang, Y.; Ren, X.; Guo, L. H.*; Zhang, H,
“Crucial Role of P2X7 Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages”
Small, 2016, 43, 5998–6011.

(22)   Xuejing Cui, Bin Wan*, Liang-Hong Guo*, Yu Yang, and Xiaomin Ren
“Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X7 Receptor”
Environ. Sci. Technol., 2016, 50, 12473–12483. 

(23)   Hui Zhang, Jing Sun, Liang-Hong Guo*
“UV irradiation mediated aggregation of TiO2 nanoparticles in simulated aquatic system”
NanoImpact, 2016, 3/4. 75-80.

(24)   Sufang Wang, Qiyan Lv, Yu Yang*, Liang-Hong Guo*, Bin Wan, Xiaomin Ren, Hui Zhang
“Arginine decarboxylase: A novel biological target of mercury compounds identified in PC12 cells”
Biochemical Pharmacology, 2016, 118, 109–120.

(25)   Xiao-Min Ren, Wei-Ping Qin, Lin-Ying Cao, Jing Zhang, Yu Yang, Bin Wan, Liang-Hong Guo*
“Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications” 
Toxicology, 2016, 366/367, 32-42.

(26)    李忠民,郭良宏*
“氟调醇的环境污染与毒理学研究”
《化学进展》,2016, 28, 993-2005. 

(27)    Xiao-min Ren, Linying Cao, Yu Yang, Bin Wan, Sufang Wang, Liang-Hong Guo*
“In vitro assessment of thyroid hormone receptor activity of four organophosphate esters”
Journal of Environmental Sciences, 2016, 45, 185-190.

(28)   Changjiang Hou, Lixia Zhao*, Fanglan Geng, Dan Wang, Liang-Hong Guo*
“Donor/acceptor nanoparticle pair-based singlet oxygen channeling homogenous chemiluminescence immunoassay for quantitative determination of bisphenol A”
Analytical Bioanalytical Chemistry, 2016, 408, 8795-8804.

(29)  Hui Zhang, Lixia Zhao, Fanglan Geng, Liang-Hong Guo?, Bin Wan, Yu Yang
“Carbon dots decorated graphitic carbon nitride as an efficientmetal-free photocatalyst for phenol degradation”
Applied Catalysis B: Environmental, 2016, 180, 656–662.

主持完成的科研项目

 

个人简历

国家杰出青年基金获得者,国家重大科学研究计划首席科学家,中国科学院“百人计划”入选者,英国皇家化学会Fellow。主要从事环境毒理学和环境分析化学的研究。在环境毒理学方向,研究多溴联苯醚、全氟有机物、大气颗粒物、环境纳米材料等新型和典型区域污染物与激素受体、代谢酶、转运蛋白等具有重要功能的生物大分子之间的相互作用,这些作用对细胞和活体正常生理功能的干扰,以及作用产生的毒性效应和健康危害。在环境分析化学方向,主要研究快速、高灵敏度、高通量的生物检测方法,实现对持久性有机污染物的定量检测;研究基于机制的毒性传感技术,实现对致癌物、内分泌干扰物等有毒化合物的快速毒性筛查。作为通讯作者在Environmental Health Perspectives, Achieves of Toxicology, Nanotoxicology, Environmental Science & Technology, Nano Letters, ACS Catalysis, Analytical Chemistry等国际知名期刊上发表SCI论文100余篇,共同主编专著《环境纳米科学与技术》,撰写中英文专业书籍章节10个。指导研究生39名。任《环境化学》主编,英国皇家化学会期刊Environmental Science: Processes and Impacts副主编,《分析化学》编委,《生态毒理学》编委,大气环境化学与健康联合实验室主任,中国毒理学会分析毒理专业委员会常务委员,中国化学会环境化学专业委员会委员,中国化学会分析质谱专业委员会委员,中国环境科学学会环境医学与健康分会委员,中国仪器仪表学会分析仪器分会电化学分析专业委员会委员。荣获中国科学院杰出科技成就奖、中国分析测试协会科学技术奖二等奖、国家百千万人才工程“有突出贡献中青年专家”称号。享受国务院政府特殊津贴。

其他

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